Human trials
A human autophagy signal, with important limits
Intermittent time-restricted eating may increase autophagic flux in humans: an exploratory analysis
Published
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Fasting Free source summary: https://fastingfree.com/education/bensalem-2025-autophagy/
PLAIN-LANGUAGE SUMMARY
What it found
An exploratory six-month comparison favored the combined intermittent approach over standard care. There was no significant increase from baseline within that group, and a decline in the control group may partly explain the difference.
Keep these limits in view
This blood-cell finding does not identify when autophagy starts, establish effects throughout the body, or demonstrate longer human life. The intervention combined changes in calories and timing, and the favorable comparison was post hoc.
Understand the context
- Evidence type
- Exploratory analysis within a randomized trial
- Population or scope
- Adults with obesity at increased risk of type 2 diabetes
- Sample or coverage
- 121 participants in this analysis
- Study duration or data period
- 6 months
- Comparison
- Intermittent energy restriction combined with time restriction, daily calorie restriction, or standard care; autophagic flux was measured in blood immune cells.
Research terms in this source
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