Human trials
A controlled look at LDL and ApoB on keto
A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial
Published
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Fasting Free source summary: https://fastingfree.com/education/buren-2021-ketogenic-lipids/
PLAIN-LANGUAGE SUMMARY
What it found
Compared with control, the ketogenic diet increased LDL cholesterol by 1.82 mmol/L (95% CI 1.24–2.39) and ApoB by 0.50 g/L (95% CI 0.35–0.65). Both large and small LDL cholesterol fractions increased.
Keep these limits in view
A small, short study of one high-saturated-fat diet cannot represent every ketogenic pattern or estimate cardiovascular-event risk. Six withdrawals occurred with symptoms during the ketogenic phase; the results describe completers.
Understand the context
- Evidence type
- Randomized crossover controlled feeding trial
- Population or scope
- Healthy young women with normal BMI, recruited from dietetics students in Sweden
- Sample or coverage
- 24 randomized; 17 completed both diets
- Study duration or data period
- Four weeks per diet, separated by a 15-week washout
- Comparison
- Provided ketogenic food, rich in saturated fat, versus provided food following Swedish dietary recommendations. Ketosis was confirmed; weight fell despite a weight-maintenance goal.
- Measured outcomes
- Primary: LDL cholesterol. Secondary: ApoB, LDL subfractions, and other blood markers.
Research terms in this source
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