Human trials
Inflammation and platelet signals during prolonged fasting
Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study
Published
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Fasting Free source summary: https://fastingfree.com/education/commissati-2025-prolonged-inflammation/
PLAIN-LANGUAGE SUMMARY
What it found
Inflammatory and platelet-activation markers increased. Urinary 11-dehydro-TXB2 remained elevated after refeeding. These were biological signals, not observed rates of thrombosis or cardiovascular events.
Keep these limits in view
Small uncontrolled sample, variable durations and clinical medication changes complicate attribution. Inferred muscle, bone and amyloid pathways are not direct demonstrations of preserved tissue or improved brain health.
Understand the context
- Evidence type
- Single-arm clinical study with exploratory molecular analyses and external cohort comparisons
- Population or scope
- Selected clinic volunteers; mean age 52.2 years and mean BMI 28.8
- Sample or coverage
- 20 participants; untargeted proteomics in 15; targeted clinical and urinary measures in 20
- Study duration or data period
- Mean 9.8 days of water-only fasting, followed by mean 5.3 days of supervised refeeding
- Comparison
- Within-person changes; no nonfasting control. External comparisons reused earlier water-only and modified-fasting cohorts.
- Measured outcomes
- Inflammatory markers, plasma proteomics, urinary platelet-related markers and metabolic measurements.
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