Human trials
Seven days of fasting: a changing blood proteome
Systemic proteome adaptions to 7-day complete caloric restriction in humans
Published
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Fasting Free source summary: https://fastingfree.com/education/pietzner-2024-seven-day-proteomics/
PLAIN-LANGUAGE SUMMARY
What it found
Many measured proteins changed, with a broad pattern emerging after several days. Mean weight fell 5.7 kg; much of the measured lean-mass decrease reversed during the brief refeeding follow-up.
Keep these limits in view
Molecular changes do not establish a benefit threshold, disease prevention, or longer life. The small selected sample, lack of a control group, and short follow-up limit causal and clinical conclusions.
Understand the context
- Evidence type
- Small, uncontrolled human intervention with exploratory proteogenomic analyses
- Population or scope
- Apparently healthy adults; predominantly White European participants
- Sample or coverage
- 12 participants: 5 women and 7 men
- Study duration or data period
- 7-day water-only fast; measurements through 3 days after eating resumed
- Comparison
- Repeated measurements against each participant’s baseline; no randomized or nonfasting control group.
- Measured outcomes
- Plasma proteins, clinical chemistry, weight and DXA body composition; disease implications modeled using external genetic evidence.
Research terms in this source
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